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NAD+ is a coenzyme present in every cell of the human body, functioning as the essential substrate for mitochondrial energy production, DNA repair, and the activation of sirtuins the family of proteins most directly associated with longevity regulation in the biological literature

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The phosphorylation of p62 at the Ser349 site has been shown to increase the binding affinity of p62 for Keap1, thereby promoting Keap1 degradation