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The activation of protein kinases may lead to the phosphorylation of transcription factors, which are proteins supporting gene expression

The tissue collection was conducted as described above

This is especially true for liposomal versions, as the healthy fats in the food can complement the phospholipid bilayer of the supplement

Common biomarkers measured in oxidative stress research include hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH ), peroxyl radicals (ROO ), protein carbonyl content (PC) as a marker of oxidative modifications of proteins, malondialdehyde (MDA) as a marker of ROS-mediated damage of membrane lipids, 8-hydroxyguanosine (8-OHG) as a RNA damage product and 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage [38]

472 Besides, ipatasertib was also tested in combination with neoadjuvant chemotherapy in the phase 2 FAIRLANE study, where this regimen showed numerically higher ORR compared to placebo