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11,12 Despite the consistent results showing benefit of NADs in reducing HE and its related mortality, these RCTs did not assess the confounding effect of factors precipitating HE since strategies directed at management of precipitating factors may improve HE with or without NADs

Safety assessments conducted in clinical trials provide valuable insights into AEs within a specified population

Ethics declarations Competing interests D.Z.I.C

Combination studies with semaglutide consistently outperformed the GLP-1 drug on its own, which is the cleanest available evidence that an amylin analog adds to, rather than duplicates, incretin-based weight loss

Additionally, they downregulated the expression of Iba-1 as a microglial activation marker and GFAP as an astrocyte activation marker, thereby suppressing the activation of microglia and astrocytes