Hepatic actions of glucagon on glucose production Glucagon increases blood glucose by enhancing two central hepatic biochemical processes, glycogenolysis and gluconeogenesis
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Proven treatments, including retinal photocoagulation (PRP), VEGF inhibitors, and corticosteroids, have demonstrated efficacy in both clinical trials and real-world applications [37]
The relationship between GT and chemotherapy resistance is demonstrated by a number of experiments showing that transfection with GT both in vitro and in vivo leads to resistance to members of the platinum drug family, and in particular to cisplatin (Hanigan et al., 1999b
These consequences may, in turn, increase healthcare utilization and associated costs through additional diagnostic testing, clinic visits, or hospitalizations