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Compared with people starting topiramate, those starting GLP-1 drugs were 48% less likely to start valproate, 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies, 35% less likely to start tricyclic antidepressants, and 23% less likely to start the class of drugs called gepants

Carriers of certain variants in GLP1R and GIPR genes may experience more pronounced rebound appetite shifts when discontinuing treatment

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And were already at a point where I think many Americans are increasingly skeptical of institutions of expertise of medical adjacent agencies after some of the things that happened with covid, he said