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Exp Eye Res 1998;67:58795 [DOI] [PubMed] [Google Scholar] 4.Samiec PS, Drews-Botsch C, Flagg EW, Kurtz JC, Sternberg P Jr, Reed RL, Jones DP

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The pathogenic characteristics of OA include synovitis, chondrocyte death, deterioration of the extracellular matrix (ECM), subchondral osteosclerosis, and osteophyte formation [4], resulting in elevated incidence and disability rates [5]

These findings suggest that GYY4137 may serve as a chondroprotective agent by modulating macrophages responses to inflammatory stimuli