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These findings suggest that PK activators could be potential novel therapeutic options for management of other hereditary RBC disorders such as HS characterized by excess oxidative stress, perturbation of the glycolytic pathway, and/or relative PK deficiency

BCTC is also a potent antagonist of TRPV1 activated by protons 45

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Hepatotoxicity indices were measured because, beside the kidneys, the liver is the chief organ in charge of carnitine production, justifying the rationale behind assessing both organs performance