In the spring of 2025, both tirzepatide and semaglutide came off the drug shortage list ending the legitimate use of compounded agents in the absence of specific exceptions
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess or other pyogenic infection as well as in diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer
Oxidative stress, inflammation, and a decline in mitochondrial function are major contributors to this process
In asthma, peroxisomal dysfunction may impair antioxidant defenses in airway epithelium, increasing vulnerability to environmental triggers (e.g., air pollutants) (104)