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Journal of Vascular Surgery, 50 (5), 10961102

Preclinical studies indicate that pharmacological modulation of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) can normalize aberrant DNA methylation and histone acetylation at promoters of neuroprotective genes, restore BDNF signalling, reduce neuroinflammation, and improve cognitive performance after developmental or adult ethanol exposure [11,65,83]