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Despite their significant clinical potential, they are associated with certain limitations, including suboptimal pharmacokinetics and patient adherence challenges, necessitating the development of advanced drug delivery systems to optimize efficacy and improve compliance

Acknowledgement We thank Ernesto Bernal-Mizrachi for reading the manuscript and commenting on the use of the GLP-1 mimetics in treating Type 2 diabetes

NOXs are present in most eukaryotes, including amoeba, fungi, plants, nematodes, echinoderms, urochordates, insects, fish, reptiles, and mammals 40,41