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Sun (2021) a Chinese group working with APP/PS1 amyloid-pathology mice showed restoration of spatial learning with oral dosing (1.442.88 mg/kg, 3 months): neuron and synaptophysin counts rose, astrocyte and microglial activation fell, IL-1 and TNF- dropped and anti-inflammatory IL-10 increased

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and their frequency , as they are already pre-expanded to higher magnitudes than in nave individuals

302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis