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Sodium-glucose cotransporter-2 (SGLT2) inhibitors EMPACT-MI [60] The event-driven EMPACT-MI trial investigated the effect of empagliflozin (10 mg/daily) added to standard of care in 6522 patients who had been hospitalized with an acute MI within 14 days before randomization and had either evidence of a new onset left ventricular ejection fraction (LEVF) of less than 45 % or signs or symptoms of congestion leading to treatment during the index hospitalization (or both) [60]