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Furthermore, dihydroethidine (DHE) staining showed that the proportion of DHE-positive cells after OGD treatment was higher than that in the control group, suggesting that the level of reactive oxygen species (ROS) was increased (Figure 3G)

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In non-alcoholic steatohepatitis (NASH), Kupffer cells (KCs) in the liver are polarized to the M1 phenotype, which enhances lipid uptake, increases the level of free fatty acids in hepatocytes, and increases the accumulation of ROS, ultimately exacerbating ferroptosis (238)

If confirmed in larger trials, this finding would suggest NAC might replenish maternal GSH, especially in severe IPTB cases receiving both i.v

It's unclear how a hydrophilic peptide would interact with an enzyme that processes steroid hormones