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The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

But is microdosing safeor even advisable

Without adequate B12 levels, the body may not be able to regulate neurotransmitters like serotonin properly, leading to disruptions in appetite signaling and potential weight gain

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Discontinuation rates highest in 9 mg group (28%)