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The most common treatment is lifelong B12 intramuscular injections although small amounts of B12 can be absorbed without intrinsic factor

Flushing: Temporary redness or warmth in the face or chest

The most commonly reported effects are mild injection site reactions (redness, minor swelling), occasional headaches during the first few days, and rare instances of mild fatigue

From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite