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To synthesize the dimeric macrocycles, a 22-mM solution of the respective C-terminal cysteine-modified monomer peptide in DMSO was incubated with 10 mM of the bis-maleimide linker in 50 mM Hepes-HCl (pH 7.5) with 90% (v/v) DMSO
LAC donates acetyl groups to histones, regulating the expression of genes important for synaptic plasticity, including those genes that regulate levels of glutamatethe major excitatory neurotransmitter in the brain
It activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors
Plays a critical role in protecting brain cells from oxidative stress
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