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Sarbaziha notes that levels peak in young adulthood before declining, and she outlines how the compound modulates gene expression tied to repair processes in addition to exerting acute effects on oxidative stress

To date, only a single, methodologically limited, placebo-controlled trial has evaluated its effects on maximal physical performance in healthy athletes, and its results actually point toward negative trends in both physical and mental performance ( Consequently, Meldonium's international reputation as a powerful performance enhancer appears to be built primarily on anecdotal use, theoretical biochemical mechanisms, and the inappropriate extrapolation of data from compromised animal models and ischemic patients

Bakeer, S

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A., Haddad, G