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Managing gastrointestinal disorders such as atrophic gastritis or celiac disease can improve B12 absorption

Single-carbon units, such as tetrahydrofolate (THF) and S-adenosylmethionine (SAM), are derivatives of the folate cycle [3]

However, their clinical translation is limited by challenges in intracellular delivery to target cells and the potential for off-target gene silencing effects in non-target tissues

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Specifically, speckles smaller than 100 voxels in 3D space (black) and less than 300 voxels in 3D space (white) were removed