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Retatrutide therefore builds on existing incretin-based therapies and signals a shift in obesity drug development by simultaneously targeting multiple hormone receptors

(2023) 380:eabn9257

Some data indicate that GLP-1 receptor agonists can help improve testosterone levels, particularly in men with obesity or type 2 diabetes

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Use of JARDIANCE for this indication is supported by evidence from a 26-week double-blind, placebo-controlled clinical trial, with a double-blind active treatment safety extension period of up to 52 weeks in 157 pediatric patients aged 10 to 17 years with type 2 diabetes mellitus and a pediatric pharmacokinetic study [see Clinical Pharmacology (12.3) and Clinical Studies (14.2)]