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In addition, certain ART drugs, especially early nucleoside reverse transcriptase inhibitors, inhibit polymerase , driving mtDNA depletion and mutation accumulation that underlie toxicities such as lipodystrophy, neuropathy, and accelerated aging

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doi: 10.1126/science.aav8692 41 MaLHostetlerAMorganDMMaiorinoLSulkajIWhittakerCAet al

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