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Genistein has a higher binding affinity for ER than ER and its activity depends on endogenous estrogen levels and ER expression (Irrera et al., 2017

Furthermore, by aggressively quenching ROS, GlyNAC prevents the downstream activation of Nuclear Factor-kappa B (NF-kB), a primary cellular transcription complex that triggers widespread inflammation

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Indeed, after its intestinal absorption, NAC undergoes first-pass metabolism in the liver where it is deacetylated to cysteine