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10.1146/annurev.mi.39.100185.001023 7 BergD

Treatment with sacubitril/valsartan resulted in lower IGFBP7 concentrations than did treatment with valsartan.109 In the same way, in HFpEF patients from the RELAX trial, higher baseline IGFBP7 was modestly correlated with worse diastolic function but its change at 24 weeks was significantly correlated with changes in diastolic function and exercise capacity.110 Another study, comparing controls with normal diastolic function and asymptomatic LV diastolic dysfunction with HFpEF patients, showed a rise in IGFBP7 levels in HFpEF patients that ran parallel to worsening diastolic function.111 Obesity Fatty-acid-binding Protein 4 Fatty-acid-binding proteins (FABPs) are intracellular lipid chaperones.112 FABP4 (also known as adipocyte FABP or aP2), plays an important role in the development of obesity, insulin resistance, diabetes and atherosclerosis.113 Moreover, FABP4 is associated with cardiac remodelling and both left and right ventricular dysfunction.114 FABP4 is highly expressed in response to increased lipolytic signals of catecholamine and NPs

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Lin Z, Li S, Xiao H, Xu Z, Li C, Zeng J