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In the present study, it was revealed that the level of oxidative indicator MDA is increased in OXA-treated mice

Experimental research has explored ozone enemas in rat colonic mucosa models: Europe PMC (also available via Springer: Springer)

If cellular assays are predictive of potential toxicity, the use of animal models allows the evaluation of toxicity signs occurring in response to the gradual increase in the dose of the substance, considering that the biological response could be species-specific and an active ingredient in animals could be completely inactive in humans