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When the microvilli come in contact with amino acids, long and short chain fatty acids, glucose and other stimuli, such as bile acids, acetylcholine, or signals created when the intestine stretches, they release GLP-1, along with other hormones, into the bloodstream[2]

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One study noted that consuming a high-glycemic-index carbohydrate meal 4 h before bedtime significantly shortened sleep onset latency, making it easier to fall asleep compared to eating the same meal 1 h before bed