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For topical administration, a dose would be however much that minimally covers the target area

A subsequent multivariate analysis by Larsen et al suggested that total motile spermatozoa was the most clinically relevant semen parameter and was the best predictor of fertility in the general male population

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Although the list of prohibited substances and methods is updated at least annually, its open-ended nature continues to pose challenges in definitively determining the status of many substances found in dietary supplements or medications, which may lead to unintentional violations of anti-doping rules