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The counter GSSSG treatment did not increase activation activity of 1 ng/ml HGF ( left orange-bar ), consistent with the earlier observation that GSSSG did not effectively modulate the HGF-c-met interaction (Figure 1e right column, orange bars 4 and 5 ), and hence served as a control trisulfide

Since the methylation cycle is closely linked to that of the trans-sulfuration pathways and glutathione metabolism, riboflavin levels could be important

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