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Some people are more likely to have a sulfa allergy, especially if they have a history of allergic reactions to medications

It is most effective when paired with a structured diet, increased physical activity, and healthy lifestyle changes recommended by medical professionals

Semaglutide may be prescribed off-label to aid in weight loss by an experienced and approved doctor

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 91 million participants

Immunologic Very common (10% or more): Positive for antidrug antibodies (up to 15.3%) Common (1% to 10%): Positive for antibodies against native glucagon-like peptide-1 (GLP-1) The proportion of patients testing positive for antidrug antibodies at any time postbaseline was up to 11.2% for the 2.4 mg dosage and up to 15.4% for the 7.2 mg dosage