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It is particularly important not to discontinue semaglutide without medical guidance, as abrupt cessation may lead to deterioration in glycemic control or weight regain

doi: 10.3122/jabfm.2015.01.140181

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2018 Apr;26(4):1323-1334

This more favorable hormonal milieu explains why GLP-1 weight loss tends to preserve more muscle mass, produce less hunger and psychological distress, and create a more sustainable long-term trajectory than equivalent weight loss from dieting alone