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Recent advancements in sustained-release formulations, like PLGA nanoparticles for delivering exendin-4, show promise in preclinical models but still require validation in human studies (Wang et al., 2023)

This was accompanied by decreased regional blood flow in the dorsolateral prefrontal cortex, the brain region responsible for executive functions, indicative of extra energy source availability (129)

This may overcome previous delivery limitations and significantly enhance biomarker and clinical effects

A January 2026 meta-analysis from the University of Oxford, published in the BMJ, analyzed 37 studies involving 9,341 adults

After reconstitution, refrigeration is required