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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

Using high-resolution mass spectrometry for precise molecular weight determination, combined with the structural inference based on Figure 2, the research team identified the chemical nature of impurity peak 3

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doi: 10.1002/9780470123102.ch1

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