In general, the rate of synthesis, regeneration, and recycling of glutathione is determined by three key factors 2 : Cellular levels of cysteineCysteine availability is the rate-limiting step in glutathione production, so not enough cysteine and de novo synthesis of glutathione will slow Enzyme glutamate cysteine ligase (GCL) activity, in part regulated by glutathione feedback inhibition Glutathione depletion due to high levels of oxidative stress, inflammation, or exposure to xenobioticsin these situations, de novo synthesis is upregulated Of course, as an antioxidant, one of the most important roles of glutathione is shielding cells from reactive oxygen species and reactive nitrogen species, but thats not its only job
It also improves insulin sensitivity and metabolic flexibility in ways that complement GLP-1 mechanism
That matters enormously
Exploring the Benefits of Berberine and Glutathione The Health Benefits of Berberine Supports Metabolic Health : Berberine has been shown to help regulate blood sugar levels by improving insulin sensitivity, which can be particularly beneficial for individuals looking to manage their weight or blood sugar levels
Santonastaso M, Mottola F, Iovine C, Colacurci N, Rocco L
