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Similarly, while the previous study 19 showed higher levels of protein C, which is a prothrombinase complex inhibitor, in splenectomized patients as compared to healthy volunteers and non splenctomized patients, our study showed increase activation of the prothrombinase complex as shown by the increased levels of prothrombin fragment 1 + 2 in the splenectomized patients

Rose NR, Bonita R, Burek CL (2002) Iodine: an environmental trigger of thyroiditis

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