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published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling

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Potential Side Effects and Safety Considerations General Tolerance GHK-Cu is considered safe and non-toxic , with a safety profile similar to placebo in clinical trials (Abdulghani et al., 1999)

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