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In one comparative study, n-propyl gallate provided the most robust protection across multiple readouts of neuroprotection, outperforming gallic acid and other analogues (40)

Besse-Patin et al report that PGC1A promotes ER expression while also acting as an ER coactivator to mediate an antioxidant response involving increased expression of antioxidant genes such as superoxide dismutase 2 and glutathione peroxidase-1 (84)

It is an antioxidant the kidneys naturally rely on to protect their own tissues during the filtration process

Here, we demonstrate that this gain-of-function programme has a significant weakness

International Journal of Cancer