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Aged muscle stem cells treated with NNMT inhibitors regain proliferative capacity and regenerative function, reversing cellular senescence that normally accumulates with age

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As a result, this methyl group is transferred to homocysteine, culminating in the synthesis of methionine and tetrahydrofolate (THF)

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J Clin Invest 86 : 265272 Mauras N and Haymond MW (2005) Are the metabolic effects of GH and IGF-I separable