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Comfort Techniques That Reduce Injection-Related Discomfort Temperature management improves comfort significantly: allow refrigerated medication to warm to room temperature for 15 to 30 minutes before injecting, as cold fluid entering tissue triggers more noticeable discomfort

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Conversely, lowering lactate levels or inhibiting lactate transport (MCT1/MCT4) can relieve immunosuppression and improve responses to immune checkpoint blockade in preclinical models and early translational studies, supporting rational combinations of lactate- or lactylation-targeting strategies with immunotherapy [170]

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