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Scientifically, menopause triggers a sharp drop in estrogen, leading to vulvovaginal atrophy (thinning and drying of tissues), while chronic stress activates the hypothalamic-pituitary-adrenal axis, inhibiting arousal pathways and diverting energy from reproduction to survival.[5][9] Key contributors include: Menopause and perimenopause: Estrogen drop thins vaginal tissues, reduces lubrication, and dampens libido by altering brain chemistry

LUPKIN: The problem is that in your stomach, the drug gets broken down too efficiently, and too fast for the semaglutide to get into the bloodstream and do its job all over your body

Baeten, P

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