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By the early 2000s, innovations including NLCs, nanoemulsions, and biopolymer-based nanoparticles expanded the range of available strategies and enhanced key performance metrics such as stability, payload capacity, and bioavailability

The pathogenic roles of LMNA (E358K) and LMNA (R453W) were previously reported to cause muscular laminopathy including CMD, EDMD, and EDMD2, our results confirm the pathological roles of LMNA (E358K) and LMNA (R453W) variants and suggest that the novel variants LMNA (L35P) and LMNA (A539V) may also have pathogenic implications

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