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Based on Phase 2 trial data, retatrutide does not appear to cause serious heart problems in otherwise healthy adults

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Evidence from experiments employing somatostatin receptor 2 (SSRT2) antagonists and SSRT2 knockout mice strongly suggests that GLP-1s inhibitory actions on -cells are indirect and partially mediated through somatostatin-dependent mechanisms (132)

Clinical trial doses have ranged from 1 mg to 12 mg injected once weekly

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