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The benefit of such approach is that the normal body cells are not considerably affected since they harbor basal levels of ROS and are less reliant on antioxidants

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Human clinical trials combining these agents are rare due to ethical constraints and unpredictable risk profiles

Ferroptosis, a distinct form of regulated cell death, characterized by iron-dependent lipid peroxidation, differs from autophagy, apoptosis, and necrosis, and may hold promise as a novel cell death

A confluence of recent scientific evidence has illuminated how NRF2-driven transcriptional programs support cancer cell survival through tumor-intrinsic mechanisms and also sculpt the tumor immune microenvironment to suppress cytotoxic immune responses and dampen the efficacy of anti-PD1 checkpoint immunotherapy