Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk Published April 25, 2013 N Engl J Med 2013;368:1575-1584 DOI: 10.1056/NEJMoa1109400 Abstract Background Recent studies in animals have shown a mechanistic link between intestinal microbial metabolism of the choline moiety in dietary phosphatidylcholine (lecithin) and coronary artery disease through the production of a proatherosclerotic metabolite, trimethylamine- N -oxide (TMAO)
doi: 10.1056/NEJMoa1812389 9 MosenzonOWiviottSDCahnARozenbergAYanuvIGoodrichELet al
Cholin ist an der Synthese von Acetylcholin beteiligt
Clinical studies supporting the FDAs approval of Zepbound found that patients with moderate-to-severe sleep apnea experienced: A substantial reduction in apnea and hypopnea events Improved oxygen levels during sleep Decreased daytime fatigue These findings confirm that improving weight and metabolic health through GLP-1 sleep apnea treatment can deliver measurable respiratory benefits
Holistic lifestyle interventions that synergistically incorporate exercise regimens with specific nutritional enhancements can restore anabolic sensitivity, augment muscle perfusion, and decrease systemic inflammationcollectively facilitating improvements in physical function, metabolic health, and overall quality of life (91)
