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In MCAO rat brain and in OGD/R-treated SK-N-SH cells in vitro , caffeic acid decreased the expression of TFR1 and ACSL4, and increased the synthesis of glutathione via the Nrf2 signaling pathway to inhibit ferroptosis (Li et al., 2024a)

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The 16.8-fold increase in t (from 2.0 min to 33.6 min) significantly prolongs systemic circulation, reducing the need for frequent dosing [42]

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