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The role of vitamin k and its antagonist in the process of ferroptosis-damaged rpe-mediated cnv

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In cardiovascular diseases, particularly ischemiareperfusion injury [93], ferroptosis is associated with the loss of cardiomyocytes and heightened inflammation

In vitro experiments revealed that liensinine could alleviate ferritinophagy and inhibit ferrous iron release and lipid peroxidation to boost AAMs resistance to ferroptosis, potentially by blocking the autophagosome-lysosome fusion and subsequently inhibiting the recruitment of ferritin into the lysosomes for degradation (85)