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Profiling metabolites associated with the gut-brain-kidney axis, such as uremic toxins, can offer insights into disease mechanisms and identify biomarkers for early diagnosis and disease monitoring (Yang et al., 2018)

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So, Zn is necessary for the expression of ROS scavenging genes, and in the case of Zn deficiency, the expression of genes responsible for the production of antioxidant enzymes such as SOD, APX, and glutathione reductase (GR) decreases 10

10.1016/j.ooc.2022.100021 43 LouisF.PannetierP.SouguirZ.Le CerfD.ValetP.VannierJ.-P.et al (2017)