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In view of the above, we hypothesize that increased activity of ADA in RA patients drives joint remodeling leading to bone resorption through purinergic and adenosine signaling and altered metabolism

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59,60,61 Neurons injury, 62 Alzheimers like pathologies, 63 and abnormal activity of neurotransmitter receptors 64 are also closely associated with cerebrovascular lesions, and jointly cause brain function impairment in patients

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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Wilding J.P.H., Batterham R.L., Davies M., Van Gaal L.F., Kandler K., Konakli K., Lingvay I., McGowan B.M., Oral T.K., Rosenstock J., et al