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Phentermine alone produces approximately 5-8% body weight loss over 12 weeks in responders, but benefits plateau as tolerance develops

Its important to note that side effects may vary from person to person, but common ones include nausea, constipation and headaches

When body weight comes down, insulin control can improve, and cycles may become more predictable over time

The second tier is rare but serious : a sudden loss of vision in one eye, which can signal an optic-nerve problem

Tirzepatide can sometimes cause slightly stronger early side effects because of its dual action, but this depends heavily on individual tolerance and dose titration