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The GSH pool is less oxidised in the DHAR3 mutant (one allele only) under low or high light but only under high light in DHAR1 mutants, perhaps reflecting a greater rate of ascorbate oxidation in chloroplasts compared to cytosol in low light [177], [178]

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Furthermore, when using cholesterol hydroperoxide (ChOOH, a specific GPX4 substrate) as a stressor, compound 102 could activate GPX4 in intact cells and protect them from ChOOH toxic effects ( Supplementary Figure S12B )

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