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Patients with controlled uric acid level and doing well on allopurinol would seem to have no reason to switch to this new agent, in view of allopurinol's lower cost and 40-year history of an overall very good safety record (see "Allopurinol" discussion above)

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Semaglutide slows gastric emptying and increases satiety, so smaller, more frequent meals focused on nutrient density ease nausea and prevent underfueling

Early detection of deficiencies allows for timely intervention

Digestion and Absorption of Unbound B12 In supplements, B12 is not bound to protein, and therefore does not need digestive enzymes or stomach acid to be detached from a protein