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The model identifies pathways responsible for the effect of the double and triple drug combinations, versus the effect of the addition of each single agent at its IC50 concentration

Although a PBM may list the drug on their formulary, the decision to provide coverage for the medication still falls upon the plan sponsor. In addition, payers should: Review PBM formulary and utilization management systems to ensure that only clinically eligible patients get the drugs Negotiate lowest-net-cost PBM formulary changes to obtain the medications at the lowest prices Contract with a PBM that approves of manufacturer copay cards for non-specialty drugs, which can lower the cost burden on the payer The weight loss potential cannot be easily dismissed on either a clinical or financial basis, according to the guide

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Folate can mask the symptoms of vitamin B12 deficiency