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doi: 10.1021/acs.jmedchem.8b01165 171 BhopaleKKSrinivasanMP

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In 2012, while investigating the mechanism of Erastin-induced cell death, Dixon and colleagues formally coined the term ferroptosis to describe this iron-dependent, lipid peroxidation-mediated form of regulated cell death ( Compared with other forms of cell death, such as autophagy, apoptosis, and pyroptosis, ferroptosis exhibits distinct morphological, biochemical, and immunological characteristics (Xia et al., 2025)

Early skeletal muscle adaptations to short-term high-fat diet in humans before changes in insulin sensitivity